The Top 5 Most Popular Weight Loss Supplements Of 2025
We evaluate the most talked-about, searched, and promoted supplements every month.
Our goal is to separate marketing claims from real results. Each review is based on updated information, scientific evidence, and real user experiences — helping you make informed choices about supplements that support your health, energy, focus, weight management, and overall wellness.
How Can You Tell a Good Weight Loss Supplement from a Bad One?
Obesity is one of the biggest public health crises in the United States. According to the Centers for Disease Control and Prevention (CDC), about 42% of American adults are considered obese—and that number continues to rise year after year. Beyond the negative effects on physical health, such as increased risk of diabetes and heart disease, obesity also takes a serious toll on mental health, often leading to low self-esteem, anxiety, and social isolation.
Have you tried to lose weight but struggled to get lasting results? Maybe you’ve gone through restrictive diets or exhausting workouts without success? If so, you’re not alone. Many people face the same challenge, and finding an effective solution can feel impossible.
I’m Dr. Michael J. Whitmore, a Medical Nutritionist with over 15 years of experience helping people achieve their weight loss goals, and Jounal Staff of Healthcare Supplements. Throughout my career, I’ve tested and reviewed hundreds of supplements to figure out what really works.
In this guide, I’ll break down 5 of the most popular weight loss supplements people are using across the U.S. in 2025. I based my recommendations on strict criteria, including clinically proven ingredients, real user feedback, and overall value for money. By the end of this article, you’ll know exactly which product is best suited to help you reach your weight loss goals.
If you’re tired of wasting time and money on things that don’t work and are ready to make an informed choice, keep reading!
How We Evaluated the Products
To create this review, I evaluated each product based on the following key factors:
Active ingredients: I checked if the ingredients are clinically tested and safe.
Effectiveness: I looked at results reported by real users and scientific studies.
Value for money: I compared pricing and the benefits offered by each product.
Guarantees: I reviewed whether the manufacturer offers a money-back guarantee.
- Scientific Updates: I prioritized products that incorporate the latest scientific discoveries in their formulas. Science is constantly evolving, and it’s crucial to choose supplements that are based on up-to-date research.
Latest Scientific Updates: Why Is the World Talking So Much About GLP-1?
A groundbreaking scientific discovery has recently gained worldwide attention, revealing the existence of a powerful hormone in the human body that plays a crucial role in weight regulation: GLP-1.
GLP-1, is a natural hormone released in the gut that sends signals to the brain indicating satiety, stabilizes blood sugar levels, and helps the body use stored fat as a source of energy.
Today, medications like Oᴢᴇᴍᴘɪᴄ × Wᴇɢᴏᴠʏ × Mᴏᴜɴᴊᴀʀᴏ × Zᴇᴘʙᴏᴜɴᴅ have become widely known for acting on this very same hormone — GLP-1 — helping millions of people around the world control their appetite and lose weight.
However, despite their effectiveness, these treatments can cause significant side effects — such as nausea, vomiting, diarrhea, constipation, and even excessive muscle loss — while also requiring weekly injections, ongoing medical supervision, and high monthly costs that can range from $800 to $1,500 per month, depending on the dosage and brand.
Fortunately, science has already identified a natural alternative to achieve similar results — without needles, without risks, and without discomfort.
Certain plant-based ingredients have been shown to naturally stimulate the release of GLP-1, promoting satiety, metabolic balance, and fat burning in a safe, side-effect-free way — offering an innovative solution for those seeking to manage their weight naturally and sustainably, without injections, extreme diets, or harsh stimulants.
And when combined in the right proportions and proper doses, these compounds amplify their effects, delivering results comparable to modern medications — but in a 100% natural way, without adverse effects.
Among the most powerful are:
- Resveratrol – a powerful antioxidant that supports natural GLP-1 release, enhances cellular energy, improves insulin response, and promotes a healthier, more efficient metabolism.
- Berberine – a highly researched plant compound that boosts natural GLP-1 secretion, stabilizes blood sugar, and enhances fat metabolism.
- Green Tea Extract – concentrated in EGCG, a clinically studied molecule that enhances natural GLP-1 secretion while preventing its degradation, resulting in better appetite regulation, improved glucose balance, and superior metabolic performance.
Together, these ingredients work in synergy to activate the body’s natural GLP-1 response, reduce hunger signals, restore metabolic rhythm, and promote real, sustainable, long-term weight loss.
By addressing this overlooked hormonal root cause, you can finally regain control of your appetite, your energy, and your body — the natural way your metabolism was designed to function.
Before we get into the top 5, make sure you’re doing your homework when it comes to any supplement—look into the ingredients, benefits, possible side effects, and real user reviews.
Important Notice!
We have identified the circulation of counterfeit products on websites like
Amazon and eBay. For your safety and guaranteed results, please purchase only through this official website.
We are an independent site, dedicated to providing unbiased information about products that truly work. Our mission is to guide you with honest reviews
and insights, helping you make informed decisions.
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Top 5 Most Searched Weight Loss Supplements This Month
Here’s a side-by-side comparison of the most popular weight loss supplements people are searching for across the U.S. today, providing a summary of our research and analysis:
973 votes TOTAL RANKING
A+
Overall Grade
Pros
- Contains all key ingredient
- Powerful Energy Boost with NO Crash
- It works by activating the GLP-1 hormone.
- Laboratory tests reveal 100% pure ingredients with no binders or fillers.
- After 30 days of daily use, study participants report shocking results including rapid weight loss.
- Vegan, non-GMO, and gluten-free
- Made in the USA in an FDA Approved facility.
- 180-Day Money Back Guarantee
Cons
- Due to high demand and the product’s recent launch, supplies are currently limited.
- Available online in the United States, but not currently sold in retail stores
The Bottom Line
After just 30 days, participants in our analysis have reported incredible results—and the overwhelmingly positive feedback hasn’t stopped since. Users continue to give Leptozan an A+ rating for its ability to boost energy, support metabolism, and enhance overall well-being.
Leptozan earned our #1 ranking because it delivers real, sustainable results for fat loss, energy, and metabolic restoration. It was developed through studies involving over 1,700 overweight men and women, where researchers discovered a direct link between low GLP-1 activity and the body’s inability to effectively burn fat.
The scientists behind Leptozan identified this overlooked hormonal imbalance and created a formula designed to naturally activate the GLP-1 pathway—the same metabolic route targeted by modern weight-loss medications, but through safe, plant-based ingredients that work in harmony with the body. By enhancing natural GLP-1 levels, Leptozan helps regulate appetite, balance blood sugar, and restore the body’s ability to use stored fat as energy.
Its clinically backed ingredients include Resveratrol, a potent antioxidant shown to support natural GLP-1 secretion and improve cellular metabolism; Berberine, a powerful plant compound that enhances insulin sensitivity, stabilizes blood sugar, and boosts GLP-1 activity; and Green Tea Extract, rich in EGCG, a natural catechin that helps stimulate GLP-1 production and extend its action for longer-lasting satiety and energy balance. Combined with Potassium BHB, Calcium BHB, and Magnesium BHB, this formula delivers clean energy, supports appetite control, and promotes efficient fat burning for sustainable results.
This puts Leptozan ahead of its competitors, as it doesn’t just fight weight gain—it targets the root hormonal trigger that prevents the body from losing fat, helping to restore metabolic balance and support visible, lasting transformation.
Leptozan is available exclusively on the Official Website. Other retail stores do not sell the original product. Plus, you’ll find discounts on the Official Website. Visit the OFFICIAL WEBSITE now!
Overall, Leptozan is our top pick for weight loss in 2025.
Click here to visit the product website.
* Results may vary and do not necessarily reflect typical results of using this product. Please visit product website for more information.
2. FitSpresso
647 votes TOTAL RANKING
A-
Overall Grade
Pros
- Powerful Metabolism Booster
- Efficient Belly Fat Burner
- Reduces Your Appetite Efficiently
- Increases Mental Focus
- Improves Mood & Reduces Stress
- No artificial additives
- Vegan, non-GMO, and gluten-free
- Made in the USA
- Risk-Free: Backed by a 60-day money-back guarantee
Cons
- Anyone under the age of 18 not recommended
- Pregnant and breastfeeding women cannot use this supplement
The Bottom Line
FitSpresso earned second place on our list because it offers a fast, natural, and effective way to aid in weight loss. — starting with your morning coffee. Its innovative formula is designed to work with your body’s natural rhythms, combining clinically studied ingredients like Green Coffee Extract and EGCG to ignite metabolism, promote fat burning, and support healthy blood sugar levels.
Unlike many supplements that rely on stimulants or unrealistic promises, FitSpresso takes a smarter approach: by leveraging the power of your morning coffee ritual, it helps you boost energy, curb appetite, and melt stubborn fat — all in just 7 seconds a day.
Manufactured in the USA in GMP-certified facilities, FitSpresso is non-GMO, vegetarian, and trusted by thousands nationwide. It’s available exclusively through the official website, where you’ll also find special discounts and bonuses to help you get started.
FitSpresso available exclusively on the Official Website. Other retail stores do not sell the original product. Plus, you’ll find discounts on the Official Website. Visit the OFFICIAL WEBSITE now!
* Results may vary and do not necessarily reflect typical results of using this product. Please visit product website for more information.
3. Lipovive
487 votes TOTAL RANKING
B+
Overall Grade
Pros
- Controls appetite and reduces cravings naturally
- Boosts metabolism for faster calorie burning
- Regulates blood sugar for stable energy levels
- Vegan, non-GMO, and gluten-free
- Made in the USA
- Risk-Free: Backed by a 60-day money-back guarantee
Cons
- Premium pricing compared to other fat burners
- Only available through the Official Website (not sold on marketplaces)
- High demand may lead to limited availability
The Bottom Line
Key Features:
- 8-ingredient synergy targeting GLP-1 and GIP hormones
- Clinically studied botanicals (no harsh stimulants)
- 60-day money-back guarantee
What Users Report: Unlike harsh stimulants or expensive injections that come with side effects, LipoVive uses a blend of clinically studied botanicals to deliver steady energy, reduced cravings, and visible fat loss. Many users report slimmer waistlines, looser clothes, and more confidence within the first month — with results compounding over 2–3 months.
Bottom Line: With its unique 8-ingredient synergy, customer transformations, and a 60-day risk-free guarantee, LipoVive has earned its place on the list as the 3rd best option for lasting weight loss in 2025. If you’re tired of diets and quick fixes that don’t last, LipoVive is the smarter, safer, and more complete solution.
Lipovive available exclusively on the Official Website. Other retail stores do not sell the original product. Plus, you’ll find discounts on the Official Website. Visit the OFFICIAL WEBSITE now!
* Results may vary and do not necessarily reflect typical results of using this product. Please visit product website for more information.
4. FitBurn
429 votes TOTAL RANKING
C
Overall Grade
Pros
- No fillers or artificial additives
- Vegan, non-GMO, and gluten-free
- Made in the USA
- Risk-Free: Backed by a 60-day money-back guarantee
Cons
- It's not a miracle cure, nor does it replace lifestyle changes.
- Results vary from person to person.
- It may not be ideal for those seeking an "immediate turbo effect."
- Requires continuous use (not a 3-day thing)
- Possible restriction for some profiles (like any supplement)
The Bottom Line
FitBurn is a modern, plant-powered formula created to support appetite control, steady energy, and a more active metabolism. Instead of relying on harsh stimulants, FitBurn uses a synergy of natural ingredients inspired by new metabolic-activation research.
Why FitBurn Stands Out
- Multi-ingredient blend supporting appetite and metabolism
- Botanicals studied for cravings and energy balance
- No heavy stimulants or jittery effects
- 60-day satisfaction guarantee
Many users report:
- Reduced cravings, especially at night
- Smoother daily energy
- Feeling lighter and more confident
- Visible changes in waist, belly, arms, and legs
FitBurn works with your lifestyle, helping you stay consistent without extreme dieting.
FitBurn is a simple, natural, and smarter choice for anyone looking for real, sustainable weight support — and that’s why it continues to be one of the most trusted formulas of 2025.
FitBurn available exclusively on the Official Website. Other retail stores do not sell the original product. Plus, you’ll find discounts on the Official Website. Visit the OFFICIAL WEBSITE now!
* Results may vary and do not necessarily reflect typical results of using this product. Please visit product website for more information.
5. Burn XT
Our Rating
C-
Overall Grade
Pros
- Decent Anti-oxidant
- May aid with speeding up your metabolism
- No fillers or artificial additives
- Non-GMO and gluten-free
- Made in the USA
Cons
- No clinical study
- Does not contain 4 out of 5 must-have ingredients
- Not vegan
- Priced higher than similar products
- Some ingredients aren't backed by science
The Bottom Line
Burn XT fat burner is a dietary supplement aimed at aiding fat loss using all-natural ingredients. It’s best known for as a thermogenic fat burner supplement but in all reality we don’t believe it’s anything more than an over priced stimulant.
We included Burn XT because it contains high quality Dandelion Root Extract and Green Tea Extract and the company that makes Burn XT is well-known and has been in the industry for a long time. Unfortunately it lacks the unique ingredients that our #1 pick Citruna contains, Green Coffee Bean Extract & Lemon Peel Flavanoid.
Burn XT also has ingredients that don’t have enough science to prove their effectiveness. Most notably Capsimax Cayenne Pepper Fruit Extract .
A few drawbacks to consider:
Burn XT has 135 mg of caffeine, as is in this is the upper limit of what we recommend. Users might experience jitters, anxiety and/or a crash after taking it..
If you’re taking other medications or are sensitive to certain ingredients, Burn XT will increase your chances of an interaction. It contains dozens of different ingredients.
* Results may vary and do not necessarily reflect typical results of using this product. Please visit product website for more information.
Our comparison isn’t here to discredit every other supplement or ingredient on the market. But let’s be honest — the latest scientific research, widely covered by leading health and science outlets around the world, makes one thing crystal clear: only a handful of natural compounds truly work when it comes to activating the GLP-1 hormone — the body’s key trigger for real, lasting fat loss.
That’s why at Top5 Supplements, we’re committed to recommending only what’s backed by the most advanced hormonal and metabolic science. So you don’t waste time or money on outdated formulas — and instead, make informed, science-based choices that deliver results you can see in the mirror and feel in your confidence and energy.
Leptozan - A Better Alternative?
Leptozan is a potent health and energy supplement that has proven successful in delivering transformative results. Its all-natural, science-backed formula helps individuals achieve their weight loss and energy goals quickly and safely. In surveys, over 85% of users reported a noticeable improvement in their energy levels and mental clarity after using it as directed.
Additionally, its powerful blend of clinically proven ingredients helps activate the body’s natural GLP-1 hormone, which plays a vital role in controlling appetite, balancing blood sugar, and reigniting the body’s ability to burn stored fat efficiently. Through this mechanism, over 92% of customers experienced improved metabolism, better appetite control, and reduced fatigue within the first 28 days.
Within the first four weeks, more than 88% of users also reported a significant boost in overall well-being, noting enhanced focus, reduced stress, and sustainable weight loss.
Discover more about this revolutionary supplement now.
3 Tips to manage your weight successfully:
- Be mindful at mealtimes – avoiding distractions, such as your phone, reduces the risk of overeating.
- Start a food diary to track your intake and identify where changes need to be made.
- Always read nutritional labels on products so you can make healthy choices while grocery shopping.
*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as medical advice. Always consult your doctor before using any supplements. † Based on an internal customer response survey of subgroups of individuals. This is a subjective survey and in no way should it be intended to be interpreted as a clinical study. Results may vary.
For all products featured, results may vary. Please visit the product websites for further information.
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
The information on this website is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, we recommend you consult with a physician.
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